Table 3.
Biomarker after oral administration of 500 mg three times daily as monotherapy and during cotreatment with trimethoprim
| Parameter | Metformin | Metformin + trimethoprim | P value |
|---|---|---|---|
| Creatinine (mg dl−1) | 0.88 (0.82–0.95) | 1.08 (1.01–1.14) | <0.001* |
| CLcrea,CG (ml min−1) | 114 (103–125) | 93 (84–104) | <0.001* |
| CLren,crea (ml min−1) | 133 (119–149) | 106 (94–120) | <0.001* |
| Glucose (mg dl−1) | 89 (86–92) | 89 (85–92) | 0.762* |
| Insulin (mU l−1) | 6.8 (5.7–8.1) | 7.2 (5.7–9.2) | 0.441† |
| C-peptide (ng ml−1) | 1.4 (1.2–1.6) | 1.5 (1.3–1.7) | 0.185* |
| HOMA-IR | 1.5 (1.3–1.8) | 1.6 (1.2–2.0) | 0.521† |
| Lactate (mmol l−1) | 0.94 (0.79–1.10) | 1.24 (1.07–1.44) | 0.016† |
Data are shown as geometric means and 95% confidence intervals. The P values are from Student's t-test using untransformed (*) or logarithmically transformed data (†). Abbreviations are as follows: CLcrea,CG, estimated creatinine clearance (Cockcroft & Gault); CLren,crea, measured 8 h creatinine clearance; and HOMA-IR, estimated insulin resistance (homeostasis model assessment equation for insulin resistance).