Table 2.
Case–crossover analysis: effect of antidepressants on the risk of crash
| Antidepressants | Case period (n) | Control period 1 (n) | OR (95% CI) | Control period 2 (n) | OR (95% CI) | Control period 3 (n) | OR (95% CI) | Control period 4 (n) | OR (95% CI) | Control period 5 (n) | OR (95% CI) | Control period 6 (n) | OR (95% CI) | Control period 7 (n) | OR (95% CI) | Control period 8 (n) | OR (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All* | 2919 | 2933 | 0.98 (0.89, 1.09) | 2858 | 1.09 (0.98, 1.20) | 2847 | 1.09 90.99, 1.21) | 2765 | 1.19 (1.08, 1.30) | 2675 | 1.29 (1.18, 1.42) | 2661 | 1.29 (1.18, 1.41) | 2612 | 1.36 (1.24, 1.48) | 2554 | 1.42 (1.30, 1.55) |
| Tricyclics† | 1745 | 1745 | 1.00 (0.87, 1.14) | 1725 | 1.05 (0.92, 1.20) | 1722 | 1.05 (0.92, 1.20) | 1694 | 1.11 (0.98, 1.25) | 1745 | 1.00 (0.88, 1.15) | 1715 | 1.08 (0.94, 1.23) | 1723 | 1.05 (0.92, 1.20) | 1683 | 1.13 (1.00, 1.28) |
| SSRIs† | 788 | 782 | 1.03 (0.85, 1.25) | 739 | 1.25 (1.04, 1.51) | 750 | 1.17 (0.98, 1.39) | 708 | 1.35 (1.14, 1.60) | 778 | 1.05 (0.86, 1.27) | 743 | 1.22 (1.01, 1.47) | 725 | 1.28 (1.07, 1.53) | 715 | 1.31 (1.10, 1.55) |
| Others† | 214 | 225 | 0.85 (0.60, 1.19) | 222 | 0.89 (0.63. 1.25) | 204 | 1.16 (0.83, 1.63) | 199 | 1.19 (0.88, 1.62) | 222 | 0.88 (0.62, 1.25) | 220 | 0.92 (0.67, 1.27) | 217 | 0.96 (0.69, 1.34) | 193 | 1.30 (0.95, 1.79) |
*
Exposed to at least one antidepressant.
†
Exposed to an antidepressant of this class only.