Table 4.

Crystal structures of SLC family members. This table gives an overview of available SLC family member structures based on information obtained from this mini-review series. This list describes general structural data with the name of the crystallized homologues. The origins of the homologues and the expression hosts are also mentioned. Information about the oligomeric state of the protein in the crystal, its substrate, if co-crystalized, its resolution (Å) and protein data bank accession number are also provided.

Crystal structures of SLC family members
Human SLC family name	Homologue name	Homologue/expression system	Oligomeric state	Co-crystallization	Resolution	Protein Data Bank (PDB) accession#	References
SLC1	GltPh	Pyrococcus horikoshii/Bacteria	Trimer	l-glutamate	3.5 Å	1XFH	Yernool et al. (2004)
				l-aspartate, Sodium	3.29 Å	2NWX	Boudker et al. (2007)
				DL-Threo-Beta-Benzyloxyaspartate (DL-TBOA)	3.2 Å	2NWW
				l-aspartate	2.96 Å	2NML
SLC2	XylE	Escherichia coli/Bacteria	–	d-xylose	2.8 Å	4GBY	Sun et al. (2012)
				d-glucose	2.9 Å	4GBZ
				6-bromo-6-deoxy-D-glucose	2.6 Å	4GCO
SLC3/7	AdiC	Salmonella enterica subsp./Bacteria	Tetramer	FAB fragment	3.2 Å	3NCY	Fang et al. (2009)
		Escherichia coli/Bacteria	Dimer	–	4 Å	3LRC	Gao et al. (2009)
				l-arginine	3 Å	3L1L	Gao et al. (2010)
				–	3 Å	3OB6	Kowalczyk et al. (2011)
	ApcT	Methanocaldococcus jannaschii/Bacteria	–	–	2.32 Å	3GIA	Shaffer et al. (2009)
				FAB fragment	2.48 Å	3GI9
					2.59 Å	3GI8
	GadC	Escherichia coli/Bacteria	Dimer	–	3.1 Å	4DJK	Ma et al. (2012)
SLC6	LeuT	Eubacterium Aquifex aeolicus/Bacteria	–	Tricyclic antidepressant (TCA) clomipramine	1.85 Å	2Q6H	Singh et al. (2007)
				l-leucine, Sodium, Imipramine	1.7 Å	2Q72
	Mhp1	Microbacterium liquefaciens/Bacteria	–	––	3.8 Å	2X79	Shimamura et al. (2010)
SLC8/24	NCX_MJ	Methanococcus jannaschii/Bacteria	–	–	1.9 Å	3V5U	Liao et al. (2012)
SLC9	NhaA	Escherichia coli/Bacteria	–	–	3.45 Å	1ZCD	Hunte et al. (2005)
SLC10	ASBTNM	Neisseria memingitidis/Bacteria	–	Taurocholate	2.2 Å	3ZUX	Hu et al. (2011)
SLC13	VcINDY	Vibrio cholerae/Bacteria	Dimer	Citrate	3.2 Å	4F35	Mancusso et al. (2012)
SLC14	dvUT	Desulfovibrio vulgaris/Bacteria	–	N,N’-dimethylurea	2.4 Å	3K3F	Levin et al. (2009)
SLC15	PepTSo	Shewanella oneidensis/Bacteria	–	–	3.6 Å	2XUT	Newstead et al. (2011)
SLC16	GlpT	Escherichia coli/Bacteria	–	–	3.3 Å	1PW4	Huang et al. (2003)
SLC23	UraA	Escherichia coli/Bacteria	–	Uracil	2.8 Å	3QE7	Lu et al. (2011)
SLC25	ANT1	Bos taurus/−	–	Carboxyatractyloside (CATR)	2.2 Å	1OKC	Pebay-Peyroula et al. (2003)
	UCP2⁎	Mus musculus/Bacteria	–	GDP	–	2LCK	Berardi et al. (2011)
SLC28	vcCNT	Vibrio cholerae/Bacteria	Trimer	Uridine	2.4 Å	3TIJ	Johnson et al. (2012)
SLC30	YiiP	Escherichia coli/Bacteria	Dimer	Zinc	3.8 Å	2QFI	Lu et al. (2009)
SLC42	AmtB	Escherichia coli/Bacteria	Trimer	–	1.4 Å	1U7G	Khademi et al. (2004)
	Rh	Nitrosomonas europaea/Bacteria	Trimer	Carbon dioxide	1.85 Å	3B9Z	Li et al. (2007)
SLC47	NorM	Vibrio cholerae/Bacteria	–	–	3.65 Å	3MKT	He et al. (2010)

^⁎Structure determined by NMR methods.