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Conserved amino acids involved in the d-glucose binding site. The table shows that most amino acids involved in the d-glucose binding site in the bacterial homologue (XylE) are conserved in human GLUT1. Nevertheless, Q175 is not conserved in the human homologue and is represented by a dash (–). An asterisk (*) indicates homology.
| TM1 | TM5 | TM7 | TM10 | TM11 | |
|---|---|---|---|---|---|
| XylE | F24 | Q168/I171/Q175 | Q288/Q289/N294/Y298 | F383/G388/W392 | Q415/W416 |
| GLUT1 | F26 | Q161/I164/- | Q282/Q283/N288/Y292 | F379/G384/W388 | N411∗/W412 |
