Figure 1.

Population versus single cell analysis. The three panels provide different outcomes at the single cell level that explain signal enrichment from a population based chromosome conformation capture experiment that reflects interaction between two loci. Signal enrichment could reflect interaction at high frequency in only a subset of cells within the population (1). At a different time point this interaction could be occurring in the same or a different subset of cells within the population (2). A third possibility could be that interaction occurs at a roughly uniform frequency in every cell of the population (3) and this leads to an equivalent signal enrichment as the interactions in (1) or (2).