Table 2. DESeq results showing significant changes of gene expression in age- and stage-matched AA tumors.
| Gene | Log2 Fold-Change | P-value | P-adj | Relevance | Citation |
|---|---|---|---|---|---|
| RETN | 2.25 | 3.05E-06 | 2.80E-03 | Expressed in inflammatory cells; insulin resistance in mice; increased in BRCa patients; high expression in breast cancer tissue associated with poor survival and malignant characteristics | [42-44] |
| CRYBB2 | 1.81 | 1.24E-13 | 1.25E-09 | Differentially expressed in several studies investigating cancer health disparity | [19,20,37,38] |
| TREML4 | 1.79 | 8.87E-08 | 1.83E-04 | Elicits T-cell immunity and tumor protection when coupled with the breast cancer antigen HER2 | [72] |
| CXCL10 | 1.48 | 1.67E-04 | 2.87E-02 | Chemokine; involved in breast tumor invasiveness and progression | [73] |
| PAX6 | 1.33 | 1.89E-05 | 9.57E-03 | Facilitates regulatory roles in breast cancer cell line proliferation and tumor progression | [74] |
| BMP6 | 1.25 | 2.63E-04 | 3.59E-02 | Promotes E-cadherin expression through repressing delta-EF1 in breast cancer cells; abnormally expressed and regulated by estrogen receptor alpha in breast cancer cells | [75,76] |
| EMR1 | 1.19 | 2.51E-04 | 3.48E-02 | Hormone receptor; overexpressed in a cluster of genes associated with poor prognosis in breast cancer | [77] |
| APOBEC3B | 1.13 | 1.10E-04 | 2.43E-02 | Enzymatic source of mutation in breast cancer | [78] |
| SPATA18 | -1.28 | 7.66E-06 | 5.53E-03 | p53-inducible protein; controls mitochondrial quality | [79] |
| ADAMTS15 | -1.29 | 1.82E-04 | 2.95E-02 | Metalloprotease known to inhibit breast cancer cell migration | [49] |
| ABCC6 | -1.37 | 1.10E-04 | 2.43E-02 | Multidrug resistance-associated protein | [80] |
Log2 fold-change is for mean AA expression relative to mean CA expression. Log2-fold change is calculated as log2(AA/CA). Bold entries have been observed as differentially expressed previously in literature. Gene names: ABCC6 - ATP binding cassette, sub family C (CFTR/MRP), member 6; ADAMTS15 - ADAM metallopeptidase with thrombospondin type 1 motif, 15; APOBEC3B - apolipoprotein B mRNA editing enzyme, catalytic polypeptide like 3B; BMP6 - bone morphogenetic protein 6; CRYBB2 - crystallin, beta B2; CXCL10 - chemokine (C X C motif) ligand 10; EMR1 - egf like module containing, mucin like, hormone receptor like 1; PAX6 - paired box 6;RETN - resistin; SPATA18 - spermatogenesis associated 18; TREML4 - triggering receptor expressed on myeloid cells like 4.