Table 3. Differentially expressed genes in AA tumors are part of pathways with relevance to breast cancer.
Pathway Name | Genes and Transcripts | P-value | P-adj |
p73 transcription factor network | ADA, AEN, BUB1, CDK1, HSF1, PML, RAD51 | 4.75E-05 | 1.62E-02 |
Aurora B signaling | AURKB, BUB1, INCENP, KIF20A, KIF23 | 1.07E-04 | 1.83E-02 |
PLK1 signaling events | BUB1, CDC25B, CDK1, INCENP, KIF20A | 2.35E-04 | 2.68E-02 |
Aurora C signaling | AURKB, INCENP | 4.68E-04 | 3.21E-02 |
BARD1 signaling events | EWSR1, FANCA, RAD50, RAD51 | 4.70E-04 | 3.21E-02 |
The underlined entry was the only gene not increased in AA samples. Results from the Pathway Interaction Database (http://pid.nci.nih.gov/). Gene names: ADA - adenosine deaminase; AEN - apoptosis enhancing nuclease; AURKB - aurora kinase B; BUB1 - BUB1 mitotic checkpoint serine/threonine kinase; CDC25B - cell division cycle 25B; CDK1 - cyclin-dependent kinase 1; EWSR1 - EWS RNA-binding protein 1; FANCA - Fanconi anemia, complementation group A; HSF1 - heat shock transcription factor 1; INCENP - inner centromere protein antigens 135/155kDa; KIF20A - kinesin family member 20A; KIF23 - kinesin family member 23; PML - promyelocytic leukemia; RAD50 - RAD50 homolog (S. cerevisiae); RAD51 - RAD51 recombinase.