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. 2004 Apr 15;113(8):1118–1129. doi: 10.1172/JCI19205

Figure 3.

Figure 3

Identification of bone marrow–derived vector-expressing cells in the PNS of transplanted mice. Representative cryostatic sections of the dorsal root ganglion (A), sciatic nerve (B), and acoustic ganglion (C) of a transplanted mouse, 6 months after BMT, immunostained for GFP, F4/80, and NeuN, as indicated. (A) Left panel, GFP+ cells were found in the dorsal root ganglion, surrounding sensory neurons and showing a macrophage morphology. Scale bar: 60 μm. Right panel, all of the GFP+ cells coexpressed the macrophage marker F4/80. Scale bar: 200 μm. (B) GFP+ cells were detected in the endoneurial space of the sciatic nerve and expressed F4/80. Scale bar: 100 μm. (C) GFP+ cells were distributed between sensory neurons in the acoustic ganglion and did not express the neuronal marker NeuN. Scale bar: 200 μm. (D) Vector-expressing cells in the PNS of a representative secondary transplant recipient. Cryostatic section from the dorsal root ganglion 4 months after BMT, immunostained for GFP and F4/80. Scale bar: 150 μm.