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DNBS- and DSS-induced colitis is worsened in CB1–/– and in SR141716A-treated (3 mg/kg) C57BL/6N mice. (A and B) Macroscopic score of colonic inflammation (A) and levels of MPO activity (B) in CB1+/+ and CB1–/– littermates. (C and D) Macroscopic score of colonic inflammation (C) and levels of MPO activity (D) in vehicle- and SR141716A-treated C57BL/6N mice. Data are means ± SEM.
