Figure 11.

Transgenic mice develop rubeosis iridis and neovascular glaucoma. (A) The transgenic eye developed synechias (two connected arrows) that hampered the drainage of aqueous humor (left panel). Neovessels from the iris, marked with anti-vWF (green), invade the cornea (right panel, magnification of inset in left panel). (B) Transgenic mice developed buphthalmos. The length of transgenic anterior chamber was higher than that in controls. (C) Scanning electron microscopy analysis of iridocorneal angle. (Insets in left two panels are magnified in the panels to their right.) Transgenic eyes showed an accumulation of cells (arrowheads) occluding the trabecular meshwork. In contrast, control mice presented an unobstructed trabecular meshwork (arrows). Ach, anterior chamber; EM, extraocular muscles; I, iris; ICA, iridocorneal angle; ONe, optic nerve; PB, pupillary border; Pu, pupil opening. Scale bars: 460 μm (A), 2,100 μm (B), and 900 μm (C).