Table I.
Self-sufficiency in albumin, intravenous immunoglobulin, coagulation factor VIII and factor IX + prothrombin complex concentrates and Antithrombin III in Italy from national plasma: provisional data 2013 and trend in 2018 and 2023 (see text).
| 2013 | 2018 | 2023 | ||||
|---|---|---|---|---|---|---|
| Production | Use | Production | Use | Production | Use | |
|
|
||||||
| Plasma (kg) | 791,000 | 917,000 | 1,063,000 | |||
| Albumin (tons) | 19.5 | 33 (550 g/1,000) | 22.3 | 24,5 (400 g/1,000) | 25.4 | 22 (350 g/1,000) |
| IgIv (tons) | 2.86 | 3.9 (65 g/1,000) | 3.76 | 5.2 (85 g/1,000) | 4.36 | 6.8 (110 g/1,000) |
| FVIII (IU) | 108,000,000 | 100,000,000 | 123,000,000 | 110,000,000 | 140,000,000 | 120,000,000 |
| FIX+PCC (IU) | 37,000,000 | 35,000,000 | 42,000,000 | 40,000,000 | 48,000,000 | 45,000,000 |
| AT III (IU) | 118,000,000 | 120,000,000 | 135,000,000 | 95,000,000 | 154,000,000 | 80,000,000 |
|
|
||||||
| Difference (2013) | Difference (2018) | Difference (2023) | ||||
|
|
||||||
| Albumin (tons) | −13.5 | −2.2 | 3.4 | |||
| IgIv (tons) | −1.0 | −1.4 | −2.4 | |||
| FVIII (IU) | 8,000,000 | 13,000,000 | 20,000,000 | |||
| FIX+PCC (IU) | 2,000,000 | 2,000,000 | 3,000,000 | |||
| AT III (IU) | −2,000,000 | 40,000,000 | 74,000,000 | |||
Legend IgIv: immunoglobulin for intravenous administration; FVIII: factor VIII; I.U.: international units; FIX: factor IX; PCC: prothrombin; AT III: antithrombin III.