Table 1.
Association between haplogroup status and invasive serous ovarian cancer risk
|
Euroeapn |
Haplogroup-tagging SNPs | Allele | Case/control proportions | OR (95% CI) | P |
|---|---|---|---|---|---|
| Haplogroup | |||||
| H |
rs2015062 |
C |
0.53 / 0.50 |
1.10 (0.82-1.51) |
0.54 |
| U |
rs28358571, rs2853499, rs2854122 |
T, A, C |
0.19 / 0.20 |
0.94 (0.64-1.39) |
0.77 |
| J |
rs2015062, rs2854122, rs28359178 |
T, C, A |
0.10 / 0.09 |
1.16 (0.70-1.93) |
0.61 |
| K |
rs28358571 |
C |
0.09 / 0.09 |
0.98 (0.59-1.65) |
1.00 |
| V |
rs2015062, rs2853495, rs2853506 |
T, G, A |
0.05 / 0.07 |
0.63 (0.32-1.23) |
0.18 |
| W |
rs2854122, rs41535848, rs28357684 |
T, A, G |
0.02 / 0.02 |
1.12 (0.41-3.49) |
0.79 |
| X |
rs2853517, rs2854122, rs28357684 |
G, T, G |
0.02 / 0.03 |
0.67 (0.23-1.94) |
0.59 |
| I |
rs8896, rs41347846, mt14182 |
G, C, T |
0.00 / 0.00 |
- |
1.00 |
| T | rs3088053, rs3926883 | A, C | NA / NA | - | 1.00 |
Table is ordered by haplogroup frequency in cases. Haplogroup tagging MT-SNPs and allele are as reported by Saxena et al., 2006. OR; odd ratio, is calculated for a total of 671 samples (317 cases and 354 controls) assigned a unique haplogroup. P is the Fischer’s exact P-value for testing haplogroup frequency and case status. Haplogroup T could not be assigned because rs3926883 was not genotyped. This SNP did not pass quality control. NA is not available.