Table 3.
MT-SNP-invasive serous ovarian cancer risk association results (MT-SNPs MAF >5%)
| SNP | ID | BP | Major/minor allele | Case/control MAF | N | OR (95% CI) | P | Pemp |
|---|---|---|---|---|---|---|---|---|
| rs2853517 |
mt709 |
709 |
G/A |
0.167 / 0.153 |
830 |
1.10 (0.76-1.60) |
0.61 |
0.86 |
| rs41352944 |
mt930 |
930 |
C/T |
0.056 / 0.043 |
831 |
1.30 (0.69-2.46) |
0.41 |
0.55 |
| rs28358571 |
mt1189 |
1189 |
T/C |
0.077 / 0.077 |
831 |
0.98 (0.59-1.64) |
0.94 |
1.00 |
| rs3928306 |
mt3010 |
3010 |
C/T |
0.209 / 0.212 |
831 |
1.01 (0.72-1.41) |
0.96 |
1.00 |
| rs2015062 |
mt7028 |
7028 |
A/G |
0.408 / 0.428 |
831 |
0.93 (0.70-1.23) |
0.60 |
0.64 |
| rs2853825 |
mt9477 |
9477 |
G/A |
0.105 / 0.084 |
830 |
1.27 (0.80-2.04) |
0.31 |
0.38 |
| rs2853495 |
mt11719 |
11719 |
A/G |
0.457 / 0.456 |
831 |
1.01 (0.76-1.33) |
0.97 |
1.00 |
| rs3088053 |
mt11812 |
11812 |
A/G |
0.079 / 0.075 |
831 |
1.06 (0.63-1.78) |
0.82 |
0.73 |
| rs2853499 |
mt12372 |
12372 |
C/T |
0.249 / 0.239 |
825 |
1.05 (0.76-1.45) |
0.77 |
0.86 |
| rs2854122 |
mt12705 |
12705 |
G/A |
0.097 / 0.097 |
795 |
1.01 (0.63-1.62) |
0.97 |
1.00 |
| rs2853504 |
mt14793 |
14793 |
T/C |
0.054 / 0.055 |
831 |
1.00 (0.54-1.82) |
0.99 |
1.00 |
| rs28357681 |
mt14798 |
14798 |
A/G |
0.154 / 0.169 |
829 |
0.90 (0.62-1.31) |
0.59 |
0.73 |
| rs28357684 |
mt15043 |
15043 |
G/A |
0.064 / 0.062 |
829 |
1.06 (0.60-1.88) |
0.83 |
0.86 |
| rs2853510 | mt15924 | 15924 | A/G | 0.066 / 0.068 | 831 | 0.97 (0.56-1.68) | 0.91 | 1.00 |
Sorted by mitochondrial base-pair position. ID is SNP as reported by Saxena et al., 2006, available at: http://www.broadinstitute.org/mpg/tagger/mito.html [Accessed 15 Nov, 2012]. BP, mitochondrial base-pair position according to the revised Cambridge reference sequence; MAF, minor allele frequency; N, number of observations; OR, odds ratio; 95% CI, 95% confidence interval. OR and 95% CI are for logistic regression adjusting for age at diagnosis or interview. P is the asymptotic P-value for testing MT-SNP effect significance; Pemp is empirical point-wide P-value, implement in PLINK (v1.07).