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Genetic and Pharmacologic Inhibition of SMO downregulates mediators of stem cell pluripotency. (A) SMO siRNA downregulates expression of IPA human stem cell pluripotency pathway members as compared to non-targeting (NT) siRNA treated WM3248 and A375 cells. (B) NVP-LDE-225 downregulates expression of IPA human stem cell pluripotency pathway members as compared to DMSO- treated WM3248 and A375 cells.
