Table 2.
Respective comparison of the percentage of surface receptors and cytotoxic granules positive NK cells in healthy controls and three kinds of cancer patients
| |
Healthy controls |
Pancreatic cancer |
Gastric cancer |
Colorectal cancer |
|||
|---|---|---|---|---|---|---|---|
| % | % | P | % | P | % | P | |
|
NKG2A |
1.5 ± 1.0 |
1.9 ± 1.0 |
ns U |
1.3 ± 1.2 |
ns U |
1.4 ± 1.0 |
ns U |
|
NKG2D |
92.1 ± 2.7 |
83.4 ± 8.4 |
< 0.001 T |
86.9 ± 2.9 |
< 0.001 T |
84.9 ± 10.0 |
< 0.01 U |
|
NKp30 |
71.8 ± 15.3 |
46.5 ± 20.2 |
< 0.001 U |
36.6 ± 21.3 |
< 0.001 U |
42.6 ± 19.4 |
< 0.001 U |
|
NKp44 |
1.8 ± 0.9 |
2.4 ± 1.7 |
ns U |
1.7 ± 1.4 |
ns U |
0.9 ± 1.3 |
ns U |
|
NKp46 |
84.8 ± 5.1 |
56.4 ± 22.2 |
< 0.001 U |
50.1 ± 29.5 |
< 0.001 U |
55.1 ± 24.0 |
< 0.001 U |
|
DNAM-1 |
91.4 ± 4.6 |
87.2 ± 5.5 |
< 0.01 U |
87.7 ± 7.8 |
ns U |
89.5 ± 5.1 |
ns U |
|
KIR3DL1 |
9.6 ± 2.7 |
19.8 ± 11.4 |
< 0.001 U |
17.9 ± 12.3 |
< 0.001 U |
19.5 ± 13.1 |
< 0.001 U |
|
Granzyme B |
97.9 ± 1.6 |
96.9 ± 2.4 |
ns U |
97.8 ± 2.0 |
ns U |
97.4 ± 2.5 |
ns U |
| Perforin | 95.2 ± 3.0 | 79.9 ± 16.0 | < 0.01 U | 81.2 ± 15.5 | < 0.001 U | 76.3 ± 19.1 | < 0.001 U |
U represented Mann–Whitney U-tests and T represented independent t-tests. Data were expressed as means ± standard deviations (Mean ± SD).