Table 3.
Association between the percentage of surface receptors and cytotoxic granules positive NK cells and the clinicopathological features of pancreatic cancer
|
Pancreatic cancer | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| |
NO. of patients |
NKG2D |
NKp30 |
NKp46 |
Perforin |
KIR3DL1 |
|||||
| % | P | % | P | % | P | % | P | % | P | ||
|
Distant metastasis |
|
|
|
|
|
|
|
|
|
|
|
| Absent |
20 |
82.6 ± 9.5 |
ns T |
44.2 ± 19.3 |
ns T |
53.8 ± 23.4 |
ns T |
80.5 ± 16.8 |
ns U |
20.6 ± 12.1 |
ns U |
| Present |
11 |
85.5 ± 6.4 |
|
50.7 ± 22.1 |
|
60.9 ± 20.2 |
|
78.7 ± 15.0 |
|
18.4 ± 10.3 |
|
|
Non-metastatic Pancreatic cancer | |||||||||||
| |
NO. of patients |
NKG2D |
NKp30 |
NKp46 |
Perforin |
KIR3DL1 |
|||||
| |
|
% |
P |
% |
P |
% |
P |
% |
P |
% |
P |
|
Histological grade |
|
|
|
|
|
|
|
|
|
|
|
| Well/Moderately |
9 |
85.4 ± 8.9 |
ns T |
46.2 ± 27.1 |
ns T |
71.4 ± 17.4 |
< 0.01 U |
85.3 ± 8.5 |
ns U |
23.2 ± 13.6 |
ns U |
| Poorly |
11 |
79.6 ± 9.1 |
|
40.6 ± 12.4 |
|
39.5 ± 17.1 |
|
76.5 ± 21.0 |
|
18.6 ± 10.8 |
|
|
Depth of invasion* |
|
|
|
|
|
|
|
|
|
|
|
| Tis/T1/T2 |
11 |
84.3 ± 7.6 |
ns T |
41.2 ± 18.2 |
ns T |
54.4 ± 22.6 |
ns T |
75.2 ± 19.1 |
ns U |
18.7 ± 10.4 |
ns T |
| T3 |
9 |
79.7 ± 10.9 |
|
46.0 ± 22.9 |
|
53.2 ± 25.6 |
|
86.9 ± 11.6 |
|
23.0 ± 14.1 |
|
|
Lymph node metastasis |
|
|
|
|
|
|
|
|
|
|
|
| Absent |
6 |
89.9 ± 5.6 |
< 0.05 T |
58.1 ± 19.0 |
< 0.05 T |
60.9 ± 22.6 |
ns T |
80.9 ± 21.7 |
ns U |
27.0 ± 15.5 |
ns T |
| Present |
14 |
78.9 ± 8.6 |
|
37.8 ± 17.7 |
|
50.8 ± 23.8 |
|
80.3 ± 15.3 |
|
17.9 ± 9.7 |
|
|
Blood vessel invasion |
|
|
|
|
|
|
|
|
|
|
|
| Absent |
13 |
86.7 ± 6.7 |
< 0.01 T |
40.3 ± 22.7 |
ns U |
54.7 ± 24.9 |
ns U |
86.2 ± 12.9 |
< 0.05 U |
21.9 ± 14.4 |
ns U |
| Present |
7 |
73.9 ± 7.6 |
|
48.4 ± 13.7 |
|
52.2 ± 22.1 |
|
69.9 ± 19.1 |
|
18.3 ± 6.1 |
|
|
Nerve invasion |
|
|
|
|
|
|
|
|
|
|
|
| Absent |
6 |
86.9 ± 5.7 |
ns T |
36.2 ± 22.6 |
ns U |
60.5 ± 27.6 |
ns U |
78.1 ± 16.1 |
ns U |
15.9 ± 5.6 |
ns T |
| Present | 14 | 80.2 ± 9.9 | 45.9 ± 19.0 | 51.0 ± 21.8 | 81.5 ± 17.6 | 22.7 ± 13.6 | |||||
*According to 2010 American Joint Committee on Cancer (AJCC), T4 pancreatic cancer invades celiac artery or superior mesenteric artery, and is unresectable, so T4 is not enrolled in depth of invasion for non-metastatic pancreatic cancer. Tis, T1, or T2 pancreatic cancer invades inside of the pancreas; T3 pancreatic primary cancer invades outside of the pancreas. U represented Mann–Whitney U-tests and T represented independent t-tests. Data were expressed as means ± standard deviations (Mean ± SD).