Table 4.
Association between the percentage of surface receptors and cytotoxic granules positive NK cells and the clinicopathological features of gastric cancer
|
Gastric cancer | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| |
NO. of patients |
NKG2D |
NKp30 |
NKp46 |
Perforin |
KIR3DL1 |
|||||
| % | P | % | P | % | P | % | P | % | P | ||
|
Histological grade |
|
||||||||||
| Well/Moderately |
12 |
89.0 ± 3.0 |
< 0.01 T |
45.1 ± 24.4 |
< 0.05 U |
56.3 ± 28.7 |
ns U |
88.5 ± 7.6 |
< 0.05 U |
15.3 ± 5.9 |
ns U |
| Poorly |
19 |
86.2 ± 2.5 |
|
31.2 ± 17.7 |
|
46.2 ± 30.1 |
|
76.5 ± 17.4 |
|
20.5 ± 14.3 |
|
|
Depth of invasion* |
|
|
|
|
|
|
|
|
|
|
|
| Tis/T1/T2/T3 |
10 |
87.8 ± 3.2 |
ns T |
48.0 ± 24.3 |
< 0.05 T |
54.2 ± 29.1 |
ns U |
85.5 ± 10.0 |
ns U |
21.4 ± 12.7 |
ns U |
| T4 |
21 |
87.0 ± 2.9 |
|
31.1 ± 17.8 |
|
48.1 ± 29.1 |
|
79.1 ± 17.3 |
|
17.2 ± 11.6 |
|
|
Lymph node metastasis |
|
|
|
|
|
|
|
|
|
|
|
| Absent |
11 |
89.3 ± 2.8 |
< 0.01 T |
48.2 ± 22.7 |
< 0.05 T |
57.6 ± 29.3 |
ns U |
88.5 ± 8.1 |
< 0.05 U |
15.1 ± 5.7 |
ns U |
| Present |
20 |
86.1 ± 2.5 |
|
30.1 ± 17.9 |
|
46.0 ± 29.5 |
|
77.1 ± 17.1 |
|
20.4 ± 14.0 |
|
|
Blood vessel invasion |
|
|
|
|
|
|
|
|
|
|
|
| Absent |
17 |
88.3 ± 3.0 |
< 0.05 T |
38.0 ± 23.8 |
ns T |
49.0 ± 29.6 |
ns U |
84.5 ± 12.0 |
ns U |
18.3 ± 10.8 |
ns U |
| Present | 14 | 85.9 ± 2.5 | 34.8 ± 18.4 | 51.4 ± 30.5 | 77.1 ± 18.5 | 18.8 ± 13.6 | |||||
*According to 2010 American Joint Committee on Cancer (AJCC), Tis, T1, T2, or T3 gastric cancer invades inside of gastric serosa; T4 gastric cancer invades outside of gastric serosa or adjacent organs. U represented Mann–Whitney U-tests and T represented independent t-tests. Data were expressed as means ± standard deviations (Mean ± SD).