Table 5.
Association between the percentage of surface receptors and cytotoxic granules positive NK cells and the clinicopathological features of colorectal cancer
|
Colorectal cancer | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| |
NO. of patients |
NKG2D |
NKp30 |
NKp46 |
Perforin |
KIR3DL1 |
|||||
| % | P | % | P | % | P | % | P | % | P | ||
|
Histological grade |
|
|
|
|
|
|
|
|
|
|
|
| Well/Moderately |
20 |
89.0 ± 3.7 |
< 0.01 U |
39.5 ± 19.3 |
ns T |
56.0 ± 25.8 |
ns T |
83.9 ± 11.6 |
< 0.05 U |
20.1 ± 15.9 |
ns U |
| Poorly |
12 |
77.9 ± 13.3 |
|
47.8 ± 19.2 |
|
53.6 ± 21.8 |
|
63.5 ± 22.8 |
|
18.6 ± 6.6 |
|
|
Depth of invasion* |
|
|
|
|
|
|
|
|
|
|
|
| Tis/T1/T2/T3 |
7 |
88.9 ± 4.3 |
ns U |
57.0 ± 12.4 |
< 0.05 T |
71.4 ± 19.5 |
< 0.05 T |
87.7 ± 13.0 |
< 0.05 U |
20.7 ± 11.1 |
ns U |
| T4 |
25 |
83.7 ± 10.9 |
|
38.6 ± 19.2 |
|
50.5 ± 23.5 |
|
73.1 ± 19.6 |
|
19.2 ± 13.8 |
|
|
Lymph node metastasis |
|
|
|
|
|
|
|
|
|
|
|
| Absent |
18 |
89.3 ± 4.2 |
< 0.01 U |
39.3 ± 20.2 |
ns U |
63.8 ± 24.8 |
< 0.05 U |
86.2 ± 8.8 |
< 0.01 U |
21.2 ± 16.8 |
ns U |
| Present |
14 |
79.1 ± 12.4 |
|
46.9 ± 18.1 |
|
43.8 ± 18.1 |
|
63.5 ± 21.5 |
|
17.4 ± 5.5 |
|
|
Blood vessel invasion |
|
|
|
|
|
|
|
|
|
|
|
| Absent |
25 |
86.5 ± 7.8 |
ns U |
42.0 ± 20.1 |
ns U |
53.9 ± 24.1 |
ns U |
77.8 ± 18.2 |
ns U |
19.0 ± 14.5 |
ns U |
| Present |
7 |
78.9 ± 15.0 |
|
44.6 ± 17.9 |
|
59.1 ± 25.2 |
|
70.7 ± 23.0 |
|
21.4 ± 6.3 |
|
|
Nerve invasion |
|
|
|
|
|
|
|
|
|
|
|
| Absent |
27 |
84.0 ± 11.7 |
ns U |
40.9 ± 18.6 |
ns T |
55.7 ± 23.3 |
ns U |
75.8 ± 19.7 |
ns U |
20.8 ± 13.7 |
ns U |
| Present | 5 | 84.7 ± 3.1 | 51.8 ± 23.1 | 51.4 ± 30.4 | 78.8 ± 17.8 | 12.7 ± 6.5 | |||||
*According to 2010 American Joint Committee on Cancer (AJCC), Tis, T1, T2, or T3 colorectal cancer invades inside of colorectal serosa or non-peritonealized adjacent colorectal tissue; T4 gastric cancer invades outside of colorectal serosa or adjacent organs. U represents Mann–Whitney U-tests and T represents independent t-tests. Data were expressed as means ± standard deviations (Mean ± SD).