Table 2. Adverse events of all grades, or of grade 3–4, which occurred during treatment.

Toxicity	Group A (n=42)		Group B (n=60)		All grades
	All grades	Grade 3–4	All grades	Grade 3–4	P
Neutropaenia, n (%)	14 (33)	4 (10)	35 (58)	10 (17)	0.013
Febrile neutropaenia	1 (2)	1 (2)	3 (5)	0	0.879a
Anaemia	4 (10)	0	14 (35)	2 (3)	0.072
Allergic reaction	1 (2)	1 (2)	2 (3)	0	1.000a
Fatigue	4 (10)	0	17 (28)	1 (2)	0.021
Oedema	6 (14)	0	15 (25)	1 (2)	0.188
Nausea/vomiting	11 (26)	0	29 (48)	2 (3)	0.024
Diarrhoea	2 (5)	0	7 (12)	0	0.392a
Neurological	6 (14)	2 (5)	15 (25)	2 (3)	0.118
Liver dysfunction	5 (12)	1 (2)	4 (7)	0	0.573a
Alopecia	16 (38)	0	21 (35)	0	0.749
Nail change	3 (5)	0	10 (20)	0	0.156
Hot flashes	5 (12)	0	6 (10)	0	1.000a

^aP-value from a continuity-adjusted Chi-squared test.