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. 2013 Dec 5;9(12):e1003358. doi: 10.1371/journal.pcbi.1003358

Figure 9. Synergism pattern switch triggered by psychological stress.

Figure 9

In the no or low psychological stress environment (i.e. VIP or epinephrine set close to 0 in the simulation), the index was less than 1, which indicated that BADS112A plus LY294002 has synergistic effect in the whole dose region we considered. Whereas as high psychological stress emerged (VIP or epinephrine set as 100 in the simulation), the synergism switched to a different pattern that was divided into two regions: one synergism (CI<1) in high dose region and another antagonism or additivity (CI> = 1) elsewhere.