Table 1. Effects of nifedipine on systolic tension, coronary flow and maximal (+dT/dt) and minimal (-dT/dt) contractility of isolated rat hearts from Wistar audiogenic rats and Wistar rats.
WAR | WAR + N20 | WAR + N40 | Wistar | Wistar + N20 | Wistar + N40 | |
ST | 10.0 ± 0.6 | 9.7 ± 1.1 | 8.5 ± 0.8 | 9.5 ± 0.6 | 9.1 ± 0.6 | 8.8 ± 0.9 |
CF | 7.89 ± 0.9 | 7.96 ± 0.5 | 7.11 ± 1.0 | 8.64 ± 0.8 | 8.50 ± 0.5 | 8.21 ± 0.6 |
+dT/dt | 211 ± 15 | 196 ± 22 | 212 ± 19 | 192 ± 18 | 182 ± 12 | 173 ± 10 |
-dT/dt | 231 ± 18 | 244 ± 24 | 204 ± 18 | 205 ± 16 | 202 ± 20 | 197 ± 7 |
Data are reported as means ± SEM for 6 rats per group. No significant differences were observed among any of the groups. N20 and N40 = 20 and 40 mg/kg nifedipine, respectively; ST = systolic tension (g); CF = coronary flow (mL/min); WAR = Wistar audiogenic rats.