Skip to main content
. 2012 Jul 27;45(10):948–954. doi: 10.1590/S0100-879X2012007500122

Table 1. Protocol for the induction of visceral hypersensitivity in neonatal Sprague-Dawley rats (N = 8 per group) and treatment with fluoxetine and tegaserod.

Group Daily colonic irritation with 0.5% acetic acid Treatment
Days 8-14 (dose 0.3 mL) Days 15-21 (dose 0.5 mL) Daily fluoxetine days 36-42 (10 mg·kg−1·day−1, ip) Tegaserod day 43 (1 mg/kg, ip)
Control group - - - -
Hypersensitive group + + - -
Fluoxetine group + + + -
Tegaserod group + + - +
Fluoxetine and tegaserod group + + + +