Table 1. Protocol for the induction of visceral hypersensitivity in neonatal Sprague-Dawley rats (N = 8 per group) and treatment with fluoxetine and tegaserod.
Group | Daily colonic irritation with 0.5% acetic acid | Treatment | ||
---|---|---|---|---|
Days 8-14 (dose 0.3 mL) | Days 15-21 (dose 0.5 mL) | Daily fluoxetine days 36-42 (10 mg·kg−1·day−1, ip) | Tegaserod day 43 (1 mg/kg, ip) | |
Control group | - | - | - | - |
Hypersensitive group | + | + | - | - |
Fluoxetine group | + | + | + | - |
Tegaserod group | + | + | - | + |
Fluoxetine and tegaserod group | + | + | + | + |