Table 1. Parameters of renal function of saline-, PAG-, gentamicin-, and gentamicin+PAG-treated rats 2 days after the end of the treatment.
| Saline (N = 6) | PAG (N = 4) | Gentamicin (N = 8) | Gentamicin+PAG (N = 8) | |
|---|---|---|---|---|
| Pcreat (mg/mL) | 0.49 (0.21; 0.61) | 0.48 (0.46; 0.51) | 4.06* (3.00; 5.87) | 2.20 (1.92; 4.60) |
| BUN (mg/mL) | 43.38 (34.10; 48.80) | 46.30 (41.70; 56.10) | 510.10* (400.80; 637.40) | 263.80#* (206.60; 476.20) |
| FENa+ (%) | 0.42 (0.32; 0.66) | 0.66 (0.49; 0.70) | 9.63* (7.34; 16.61) | 8.60* (6.71; 20.87) |
| FEK+ (%) | 44.37 (38.81; 52.80) | 41.87 (36.96; 43.41) | 181.10* (252.50; 234.40) | 150.20 (136.70; 217.30) |
Saline (0.15 M NaCl, im) and gentamicin (40 mg/kg, im) were injected twice a day for 9 days. PAG (10 mg·kg−1·day−1, ip) was injected for 9 days starting on day one of gentamicin treatment and the injections were performed 4 h after the first daily injection of gentamicin and 4 h before the second. PAG = DL-propargylglycine; Pcreat = plasma creatinine; BUN = blood urea nitrogen; FE = fractional excretion. Data are reported as median and interquartile ranges (25-75% percentile). *P < 0.01 compared to saline; #P < 0.05 compared to gentamicin (Kruskal-Wallis test followed by the Dunn post-test).