Figure 1. Bactericidal and opsonic antibody response to the MenB:4,7:P1.19,15 strain (Cu385/83) by mice immunized with VAMENGOC-BC^®. Lines show the average serum antibody titers (log₂) detected. A, Bactericidal antibodies at 14 days after each vaccine injection during the primary immunization schedule; B, bactericidal antibodies detected before (pre-booster) and 14 days after booster injections given at 2, 4, and 6 months (mo) after the primary immunization schedule; C, opsonic antibodies at 14 days after each vaccine injection, at 2, 4, and 6 months post-third dose and at 14 days post-booster injection applied at 6 months. The dashed line in A and B represents the protective bactericidal titer (4 or log₂ of 2). The points represent each individual antibody level, which was tested at least twice for each sample. *P < 0.05 compared to 1 and 2 doses. ^#P < 0.05 compared to 3 doses. ⁺P < 0.05 compared to pre-booster. **P < 0.05 compared to 1 dose or 2 doses. ^##P < 0.05 compared to 3 doses. ⁺⁺P < 0.05 compared to pre-booster. The paired t-test was used for statistical analysis.