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. 2013 Sep-Oct;7(9-10):312–318. doi: 10.5489/cuaj.1506

Table 1.

List of neoadjuvant chemotherapy trials included in the 2005 ABC meta-analysis

Author/year No. patients Stage NC regimen Definitive treatment OS benefit
Wallace/199129 159 T2–4NXM0 Cisplatin 100 mg/m2 45–50 Gy in 22F
65 Gy in 22F +
No
Raghavan/199130 96 T2–4NXM0 Cisplatin 70 mg/m2 RC + pelvic lymphadenectomy No
Martinez-Pineiro/199531 122 T2–4ANX-2M0 Cisplatin 100 mg/m2 RC + pelvic lymphadenectomy No
Malmstrom/199632 325 T1 (grade3)
T2–4ANXM0
Cisplatin 70 mg/m2
Doxorubicin 30 mg/m2
20 Gy in 5F
+ RC + pelvic lymphadenectomy
Yes for T3–T4 (p=0.03)
Abol-Enein/199733 196 T2–4ANXM0 Carboplatin 300 mg/m2
Methotrexate 50 mg/m2
Vinblastine 4 mg/m2
RC + pelvic lymphadenectomy Not reported
Bassi/199934 206 T2–4N0M0 Cisplatin 70 mg/m2
Methotrexate 30 mg/m2
Vinblastine 3 mg/m2
RC + pelvic lymphadenectomy Not reported
International Collaboration/1999,7 updated 20118 976 T2 (grade 3)
T3–T4ANO,NXM0
Cisplatin 100 mg/m2
Vinblastine 4 mg/m2
Methotrexate 30 mg/m2
60 Gy in 30F (or) 20 Gy in 5F + RC (or) RC and pelvic lymphadenectomy Yes on 2011 update (p=0.037)
Sherif/200235 317 T2–4ANXM0 Cisplatin 100 mg/m2
Methotrexate 250 mg/m2
RC + pelvic lymphadenectomy No
Sengelov/200236 153 T2–T4bN0NXM0 Cisplatin 100 mg/m2
Methotrexate 250 mg/m2
60 Gy in 30F (or) RC No (p=0.76)
Cortesi/unpublished 171 T2–4N0M0 Cisplatin 70 mg/m2
Methotrexate 30 mg/m2
Vinblastine 3 mg/m2
Epirubicin 40 mg/m2
Methotrexate 30 mg/m2
RC Not reported
Grossman/20039 317 T2–T4ANXM0 Vinblastine 3 mg/m2
Doxorubicin 30 mg/m2
Cisplatin 70 mg/m2
RC No (p=0.06)

ABC: advanced bladder cancer; NC: neoadjuvant chemotherapy; OS: overall survival; RC: radical cystectomy; F: fractions.