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. 2013 Jul 5;4(4):77. doi: 10.1186/scrt228

Figure 3.

Figure 3

The combination of hBM-MSCs and minocycline decreases inflammation in EAE mouse spinal cord. (A) H&E (upper panel) and CD4 staining (bottom panel) were performed to detect mononuclear and T-cell infiltration in the lumbar spinal cords of EAE mice. The arrows indicate areas with infiltrated cells. Scale bar, 200 μm. (B) Statistical analysis showing that compared with PBS treatment, hBM-MSCs or minocycline treatment alone significantly decreased the average clinical scores (P < 0.05); compared with hBM-MSCs or minocycline treatment alone, combination treatment significantly decreased the numbers of infiltrating cells by 20% to 30% (P < 0.05). (C) Compared with hBM-MSCs or minocycline treatment alone, combination treatment significantly decreased the numbers of CD4+ cells by 30% to 40% (P < 0.05). Columns, mean; bars, SEM. *P < 0.05, **P < 0.01, ***P < 0.001, one-way ANOVA with post hoc Bonferroni corrections. The results are representative of three independent experiments.