Table 1.
Cellular markers that may contribute to lung cancer stem cell properties
|
Marker |
Name |
Cellular function |
Ligand |
Cancer stem cell |
|
|---|---|---|---|---|---|
| |
|
|
|
marker |
|
| Lung | Other | ||||
| CD44 |
Pgp-1 |
Hyaluronic acid receptor |
Hyaluronic acid and hyaluronate-interacting growth factors, osteopontin |
NSCLC |
Hematopoietic, breast |
| CD133 |
Prominin-1 |
Modulator of intracellular accumulation of exogenous compounds (transferin-CD133-iron network) cell metabolism [29] Neurotrophic receptor RET tyrosine kinase expression [30] |
No natural ligand identified [31] |
NSCLC [32] |
Brain, colon, pancreas |
| CD117 |
Stem cell factor receptor |
Growth factor receptor |
Stem cell factor |
SCLC [33] |
Hematopoietic |
| CD87 |
Urokinase plasminogen activator |
uPA receptor |
uPA |
NSCLC/SCLC [34] |
Unknown |
| SP |
Side population |
Drug resistance |
EGFR [35] TRAIL [36] |
SC/NSCLC |
Hematopoietic, brain, breast |
| ALDH | Aldehyde dehydrogenase | Alcohol metabolism | Acetaldehyde | NSCLC [37] | Hematopoietic, breast, prostate |
EGFR epidermal growth factor receptor, NSCLC non-small cell lung cancer, SC stem cell, SCLC small cell lung cancer, TRAIL tumor necrosis factor-related apoptosis-inducing ligand, uPA urokinase plasminogen activator. Modified from [19].