Table 3.
EQ-5D and other assessments of function at 18 months
| Alteplase group | Control group | Odds ratio (95% CI)* | p value | Difference per 1000 patients†(95% CI) | ||
|---|---|---|---|---|---|---|
| EQ-5D | ||||||
| Mobility | 702 | 692 | .. | .. | .. | |
| No problems walking | 283 (40%) | 259 (37%) | 1·30 (1·05 to 1·61) | 0·017 | −29 (−80 to 22) | |
| Some problems walking | 343 (49%) | 346 (50%) | .. | .. | 11 (−41 to 64) | |
| Confined to bed | 76 (11%) | 87 (13%) | .. | .. | 17 (−16 to 51) | |
| Self-care | 695 | 689 | .. | .. | .. | |
| No problems with self-care | 372 (54%) | 328 (48%) | 1·43 (1·16 to 1·78) | 0·001 | −59 (−112 to −7) | |
| Some problems washing or dressing | 176 (25%) | 191 (28%) | .. | .. | 24 (−23 to 70) | |
| Unable to wash or dress | 147 (21%) | 170 (25%) | .. | .. | 35 (−9 to 79) | |
| Usual activities | 699 | 694 | .. | .. | .. | |
| No problems with usual activities | 235 (34%) | 209 (30%) | 1·32 (1·07 to 1·62) | 0·008 | −35 (−84 to 14) | |
| Some problems with usual activities | 258 (37%) | 256 (37%) | .. | .. | 0 (−51 to 50) | |
| Unable to do usual activities | 206 (29%) | 229 (33%) | .. | .. | 35 (−13 to 84) | |
| Pain or discomfort | 698 | 694 | .. | .. | .. | |
| No pain or discomfort | 344 (49%) | 304 (44%) | 1·26 (1·02 to 1·56) | 0·029 | −55 (−107 to −2) | |
| Moderate pain or discomfort | 316 (45%) | 355 (51%) | .. | .. | 59 (6 to 111) | |
| Extreme pain or discomfort | 38 (5%) | 35 (5%) | .. | .. | −4 (−27 to 19) | |
| Anxiety or depression | 693 | 690 | .. | .. | .. | |
| Not anxious or depressed | 353 (51%) | 349 (51%) | 1·05 (0·85 to 1·29) | 0·668 | −4 (−56 to 49) | |
| Moderately anxious or depressed | 292 (42%) | 290 (42%) | .. | .. | −1 (−53 to 51) | |
| Extremely anxious or depressed | 48 (7%) | 51 (7%) | .. | .. | 5 (−23 to 32) | |
| Additional questions about overall function | ||||||
| Stroke left patient with problems | 484/700 (69%) | 542/699 (78%) | 1·67 (1·30 to 2·17) | <0·0001 | 84 (38 to 130) | |
| Needs help with everyday activities | 298/696 (43%) | 350/692 (51%) | 1·59 (1·25 to 2·00) | <0·0001 | 78 (25 to 130) | |
Data are n (%) unless stated otherwise.
*
Logistic regression of outcome on treatment group, adjusted for age, National Institutes of Health stroke scale score, and delay (all linear) and visible infarct on baseline scan.
†
Standard binomial test with normal approximation.