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. 2013 Jun 21;1:19. doi: 10.3389/fpubh.2013.00019

Figure 1.

Figure 1

Reduced mortality following P.aer pneumonia in AAT transgenic mice and in mice given exogenous AAT. In (A) 10 transgenic mice that express human AAT in lung tissue (AAT+/+) and 9 C57Bl/6 (Control) mice were infected with inhaled P.aer. Kaplan–Meier survival curves are shown for 120 h following infection. Reduced mortality in AAT+/+ mice was statistically significant (p < 0.0001). In (B) C57Bl/6 mice were treated with exogenous AAT (16 mice, +AAT) or with saline (17 mice, Control). AAT was administered by nebulizer and intraperitoneal injection prior to infection with inhaled P.aer. Kaplan–Meier survival curves are shown for 120 h following infection. Reduced mortality in +AAT mice was statistically significant (p = 0.021).