Table 1.
Lung histopathology in six AAT+/+ and five C57Bl/6 control mice infected with P.aer.
| Mouse | Lobar pneumonia* | Broncho pneumonia* | Alveolar hemorrhage* | % total lung involved with inflammation | Necrosis |
|---|---|---|---|---|---|
| AAT+/+ | 0/5 | 5/5 | 0/5 | 35 | No |
| AAT+/+ | 3/5 | 2/5 | 0/5 | 65 | Yes-early |
| AAT+/+ | 2/5 | 3/5 | 0/5 | 55 | Yes-early |
| AAT+/+ | 0/5 | 5/5 | 1/5 | 35 | No |
| AAT+/+ | 0/5 | 5/5 | 0/5 | 45 | No |
| AAT+/+ | 3/5 | 2/5 | 2/5 | 70 | No |
| Total involvement | 8/30 (27)‡ | 22/30 (73)‡ | 3/30 (10)‡ | 51§ | NA |
| C57Bl/6 | 3/5 | 2/5 | 0/5 | 70 | Yes-adv |
| C57Bl/6 | 3/5 | 2/5 | 3/5 | 85 | Yes-adv |
| C57Bl/6 | 1/5 | 4/5 | 0/5 | 45 | Yes-adv |
| C57Bl/6 | 2/4† | 2/4† | 4/4† | 70 | Yes-adv |
| C57Bl/6 | 5/5 | 0/5 | 5/5 | 100 | Yes-adv |
| Total involvement | 14/24 (58)‡ | 10/24 (42)‡ | 12/24 (50)‡ | 74§ | NA |
NA, not applicable; Adv, advanced.
*Fractions represent number of lung lobes with pathology compared to number of lung lobes examined.
†Only four lobes out of five were identified.
‡Results shown as total number of lung lobes involved/total number of lung lobes examined (percent total involvement).
§Mean percent total lung involvement for all animals in each group. p = 0.052 comparing these two groups.