Figure 8.

Activation of the blood coagulation pathway after dengue virus (DENV) infection. Plasma was collected on days 0 (prebleed), 5, 6, 7, 8, 10, and 14 post-infection. Each sample was loaded on an automated STA Stago compact analyzer for measuring blood coagulation factors as described in the Materials and Methods. Shown are the temporal measures of prothrombin time (PT), activated partial thromboplastin time (aPTT), D-dimer (D-Di), fibrinogen (FIB), protein C (PROC), and protein S (PROS) as indicated. Plasma samples collected from uninfected animals were used as controls. Day post-infection is shown on the x-axis. Animal numbers for each DENV serotype are indicated in the panel of graphs on the left and remain the same across rows.