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. 2013 Dec 2;7:1409–1420. doi: 10.2147/DDDT.S50861

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© 2013 Muhammad et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Slides showing immunohistochemical staining of ER-β antigen on uterine tissue of OVX rats. (A) Sham non-treated group; (B) OVX non-treated; (C) EST 0.2 mg/kg; (D) GBR phenolics 200 mg/kg; (E) ASG 200 mg/kg; (F) REM 20 mg/kg; (G) GABA 200 mg/kg; and (H) ORZ 200 mg/kg.

Notes: Red arrows show areas of immunohistochemical staining. The sham (non-OVX group) showed light reactivity on the glandular epithelium, while the group treated with GBR phenolics showed an ER-β reactivity at the glandular and some part of the stroma and the group treated with EST showed an immunoreactivity both at the glandular, luminal, and deep in the stromal cells. Other treated groups showed mild reactivity mostly in the stroma.

Abbreviations: ASG, acylated steryl glucosides; EST, estrogen; GBR, germinated brown rice; GABA, γ-amino butyric acid; ORZ, γ-oryzanol; OVX, ovariectomized; REM, Remifemin; ER-β, estrogen receptor-β.