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. 2013 Aug 4;2(4):364–375. doi: 10.1016/j.molmet.2013.07.007

Figure 3.

Figure 3

ObRa KO mice show mildly increased susceptibility to diet-induced obesity. ObRa KO (n=16) and WT (n=14) male littermates were subjected to 60 kcal% fat diet at 6 weeks of age for 26 weeks. Body weight was measured during the course of the treatment. Body composition, GTT, plasma and CSF leptin concentrations were measured by the end of the treatment. (A) ObRa KO mice showed significantly heavier body weight during treatment weeks 13–22 (p<0.05 for paired comparison at each time-point; for example, week 16: 53.85±0.75 vs. 49.39±1.83 g). (B) ObRa KO mice showed significantly increased absolute fat mass (25.0±0.7 vs. 22.4±0.6 g, p<0.05), percentage of fat mass (43.1±0.6 vs. 40.0±0.6%, p<0.01) and unaltered lean mass (33.0±0.6 vs. 33.5±0.6 g, p>0.05). (C) ObRa KO showed significantly more elevated plasma leptin (130.54±16.50 vs. 77.06±11.3 ng/ml, p<0.01) and reduced CSF to plasma ratio (0.45±0.10 vs. 1.51±0.58, p<0.05), while the difference in CSF leptin was not significant (0.49±0.10 vs. 0.88±0.36 ng/ml, p>0.05). (D) ObRa KO and WT mice responded similarly to GTT after HFD (p>0.05 for all paired comparisons at each time-point).