Figure 1.

Electron microscopic detection of CB₁ receptors on GFAP positive cells in the cerebral cortex and the hypothalamus. Electron micrographs showing immunogold labeling of CB₁ receptors (arrows) in the Cx (A, C and E) and the VMH (B, D and F) of GFAP-CB₁-WT (A and B), GFAP-CB₁-KO (C and D), and CB₁-KO (E and F) mice. CB₁ immunogold labeling is visible on both neuronal terminals (*) and GFAP positives cells (O) in the GFAP-CB₁-WT animals while in the GFAP-CB₁-KO mice it is only detected on neuronal terminals. In full CB₁-KO animals no immunogold labeling is observed. Scale bar: 500 nm.