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. 2013 Sep 2;2(4):457–467. doi: 10.1016/j.molmet.2013.08.007

Figure 5.

Figure 5

CETP-expressing mice on a high-fat diet display improved muscle insulin signaling and altered glucose metabolism. (A) Immunoblot analysis of Akt, P-Akt (S-473), and actin in muscle whole-cell extract from fasted and clamped CETP and WT female mice. (B) Quantification of P-Akt to Akt ratio. (C) Metabolite analysis of glycolytic and TCA cycle intermediates in muscle of fasted CETP and WT female mice. (D) Schematic representation of changes in glycolytic and TCA cycle intermediates. (E) Gene expression for Dio2, Cpt1b, and Hk2 determined by qRT-PCR from muscle RNA extracts. (F) Respiratory quotient determined by indirect calorimetry for HFD fed CETP and WT female mice. Data represent the mean±SEM from n=4 animals per group, except for (F) which is n=3 animals per group. *p<0.05.