Table 1.
Additional physiological parameters. Values represent mean±standard deviation.
| WT Female | CETP Female | WT Male | CETP Male | |
|---|---|---|---|---|
| Initial body weight (g) | 20.5±2.3 | 21.0.±1.8 | 24.0±2.1 | 25.4±3.6 |
| Post-HFD body weight (g) | 26.5±5.1† | 24.1±3.6† | 28.4±3.2† | 32.1±5.0⁎† |
| HFD fasting blood glucose (mg/dL) | 152±35.8 | 134±19.6 | 148±24.1 | 151±38.1 |
| HFD clamp insulin (ng/mL) | 4.8±1.6 | 2.6±1.1 | 2.8±0.6 | 3.7±1.0 |
| Chow clamp insulin (ng/mL) | 1.7±0.4 | 2.1±0.3 | ND | ND |
| HFD plasma free fatty acid (mmol/L) | 1.44±0.96 | 1.62±0.50 | 1.57±0.77 | 1.44±0.96 |
| HFD plasma LDL (mg/dL pooled) | 33.8 | 14.6 | 39.1 | 21.7 |
| HFD plasma HDL (mg/dL pooled) | 110.3 | 50.0 | 79.5 | 52.1 |
| HFD basal glucose EndoRa (mg kg−1 min−1) | 17.3±7.4 | 19.6±5.6 | 10.3±4.4 | 14.6±10.1 |
| HFD clamp glucose EndoRa (mg kg−1 min−1) | 2.2±2.1‡ | 3.9±2.8‡ | 3.7±4.8 | 2.9±5.7‡ |
| HFD clamp glucose Rd (mg kg−1 min−1) | 17.1±3.4 | 45.0±6.1⁎ | 16.9±4.4 | 17.19±4.8 |
| HFD clamp AUC GIR/glucose (mg2 min kg−1 dL−1) | 0.10±.03 | 0.25±.05⁎ | 0.09±.03 | 0.11±.02 |
| HFD fasting plasma triglyceride (mg/dL) | 73.8±22.6 | 53.5±21.0 | 46.5±13.0 | 65.0±15.0 |
| HFD clamp plasma triglyceride (mg/dl) | 51.7±23.1 | 36.6±5.9‡ | 43.8±18.6 | 50.0±11.3 |
| HFD liver cholesterol (mg/g tissue) | 2.75±1.5 | 4.27±2.1 | 2.47±0.8 | 3.86±1.6 |
| HFD liver triglyceride (mg/g tissue) | 54.8±21.7 | 75.1±9.4 | 79.2±20.5 | 53.8±14.2 |
| HFD liver diacylglycerol (mg/g tissue) | 2.67±0.63 | 2.67±0.61 | 3.61±1.53 | 2.53 1.02 |
| HFD plasma interleukin 6 (pg/mL) | 77.6±65.7 | 76.1±31.9 | 54.3±23.5 | 113.1±64.2 |
| HFD plasma leptin (ng/mL) | 12.9±5.2 | 10.6±5.8 | 12.7±0.1 | 18.6±5.0 |
| HFD plasma adiponectin (µg/mL) | 13.1±1.8 | 15.7±1.8 | 15.1±1.6 | 17.6±3.6 |
| HFD serum estradiol (pg/mL) | 6.8±3.1 | 6.9±2.0 | ND | ND |
⁎
p<0.05 versus WT. n=4–8 animals per group.
†
p<0.05 versus pre-HFD. n=4–8 animals per group.
‡
p<0.05 versus clamp baseline. n=4–8 animals per group.