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. 2013 Sep 4;2(4):376–392. doi: 10.1016/j.molmet.2013.08.006

Figure 5.

Figure 5

Expression and functional analysis of 7TM receptors for peptide hormones in gastric ghrelin cells. (A and D) qPCR data for 379 7TM receptors examined in FACS-separated hrGFP-positive (Y-axis) and hrGFP-negative (X-axis) gastric mucosal cells. Family A receptors for peptide hormones and (D) family B receptors for peptide hormones have been marked with green. (B) Acyl-ghrelin release from primary gastric mucosal cells treated with increasing concentrations of α-MSH, 100 nM PG-901 alone (hatched) or before 1 µM α-MSH, (C) 1 µM vasopressin (AVP), kisspeptin (KP), somatostatin (Sst), 10 µM of the somatostatin antagonist BIM-23627, 1 µM CCK8, PYY3-36, neuromedin C (NMC) (significance tested with Mann–Whitney), (E) increasing concentrations of GIP, (F) secretin, GLP-1 or 10 µM isoproterenol. The data has been normalized to the basal secretion of ghrelin from vehicle-treated cells and shown as means±SEM. Number of repeated experiments is written in brackets in each bar.