Table 1. Mutants with increased Alu-IR-induced GCR rate.
| Genetic background | GCR rate (×10−6) | |||
| 100% homologous | 94% homologous | |||
| wild-type | 41 (30–52)a | 5 (4–6) | ||
| Replication mutants | ||||
| TET-RFA2 | 250 (100–280) | 6b | 170 (80–180) | 34 |
| TET-POL2 | 240 (210–270) | 6 | 130 (90–150) | 26 |
| TET-POL1 | 470 (380–500) | 11 | 100 (80–110) | 20 |
| TET-POL3 | 460 (390–640) | 11 | 82 (72–102) | 16 |
| TET-POL30 | 370 (290–390) | 9 | 69 (60–73) | 14 |
| TET-RFC2 | 280 (170–380) | 7 | 34 (21–44) | 6 |
| TET-YHR122W | 140 (110–160) | 3 | 38 (23–47) | 8 |
| Δmms19 | 720 (370–820) | 18 | 72 (61–85) | 14 |
| TET-PRI2 | 340 (260–470) | 8 | 170 (130–200) | 34 |
| TET-MCM2 | 150 (140–240) | 4 | 41 (16–62) | 8 |
| TET-ORC4 | 110 (80–230) | 3 | 62 (31–76) | 12 |
| TET-DNA2 | 120 (80–200) | 3 | 9 (9–12) | 3 |
| Δrad27 | 600 (450–920) | 15 | 90 (60–240) | 18 |
| Δpol32 | 240 (190–300) | 6 | 32 (28–36) | 6 |
| Checkpoint response genes | ||||
| Δtof1 | 250 (170–300) | 6 | 39 (31–48) | 8 |
| Δcsm3 | 370 (270–530) | 9 | 27 (22–37) | 5 |
| Δrad17 | 180 (160–250) | 4 | 14 (13–16) | 3 |
| Δrad24 | 140 (130–190) | 3 | 12 (11–17) | 2 |
| Δmec1Δsml1 | 200 (160–220) | 5 | NDc | ND |
| Δsml1 | 43 (40–49) | 1 | ND | ND |
| Helicase | ||||
| Δsgs1 | 410 (300–490) | 10 | 35 (26–44) | 7 |
| Δrmi1 | 480 (410–560) | 12 | ND | ND |
| Telomere protection genes | ||||
| TET-TEN1 | 140 (120–230) | 3 | 13 (9–16) | 3 |
| TET-CDC13 | 120 (70–140) | 3 | 14 (11–18) | 3 |
| Double strand breaks repair genes | ||||
| Δmre11 | 420 (370–440) | 10 | 210 (170–230) | 42 |
| Δrad50 | 400 (370–430) | 10 | 220 (200–250) | 44 |
a
Numbers in the brackets are 95% confidence intervals.
b
Fold increase in GCR rates in mutants compared to wild-type strains.
c
Not determined.