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Temporal evolution of the loss of hydrogel stiffness K̂ECM versus gain of ECM stiffness K̂gel for different degradation to diffusion ratios. Dashed lines (in blue) correspond to the newly created matrix stiffness, and solid lines (in red) represent the overall stiffness of the hydrogel. The figure indicates the conditions that would preserve total mechanical integrity in time and thus would be most desirable for in situ tissue engineering.
