Table 2.

Association of moderate or worse hypogammaglobulinemia with adverse outcomes of infection, rejection, and death

Adverse outcome	Univariate analysis HR (95% CI, P-value)	Multivariate analysis* HR (95% CI, P-value)
Serious non-opportunistic infection	3.5 (1.1–10.6, P=0.03)	5.2 (1.7–16.4, P=0.004)
Treated acute rejection	2.6 (0.3–20.0, P=0.37)	N/A
Death	3.2 (1.1–9.4, P=0.04)	3.2 (1.1–9.7, P=0.04)

^*Adjusted for significant predictors of serious non-opportunistic infection (post-transplant MELD score (time-varying), pre-transplant BMI, hepatitis C infection) and death (combined kidney-liver transplant, donor age, pre-transplant BMI, hepatitis C infection) among the entire cohort.

HR, hazard ratio; CI, confident interval; MELD, model for end-stage liver disease; N/A, not applicable; BMI, body mass index.