Table 1.
Correlations between Sam68 expression and clinicopathologic characteristics of neuroblastoma
| Characteristics | n | Sam68 expression
|
Chi-square test, P-value | |
|---|---|---|---|---|
| Low or none, number of cases (%) | High, number of cases (%) | |||
| Gender | ||||
| Male | 57 | 10 (11.11) | 23 (25.56) | 0.822 |
| Female | 33 | 16 (17.78) | 41 (45.56) | |
| Age (years) | ||||
| ≤1 | 19 | 9 (10.00) | 10 (11.11) | 0.045 |
| >1 | 71 | 17 (18.89) | 54 (60.00) | |
| Clinical stage | ||||
| 1 | 4 | 4 (4.44) | 0 (0.00) | <0.001 |
| 2A/2B | 19 | 11 (12.22) | 8 (8.89) | |
| 3 | 23 | 6 (6.67) | 17 (18.89) | |
| 4 | 40 | 4 (4.44) | 36 (40.00) | |
| 4S | 4 | 1 (1.11) | 3 (3.33) | |
| Tumor histology | ||||
| Undifferentiated | 48 | 7 (7.78) | 41 (45.56) | <0.001 |
| Differentiated | 29 | 16 (17.78) | 13 (14.44) | |
| GNB | 13 | 3 (3.33) | 10 (11.11) | |
| Primary tumor site | ||||
| Adrenal | 58 | 15 (16.67) | 43 (47.78) | 0.394 |
| Extra-adrenal | 32 | 11 (12.22) | 21 (23.33) | |
| Metastases | ||||
| Yes | 54 | 11 (12.22) | 43 (47.78) | 0.029 |
| No | 36 | 15 (16.67) | 21 (23.33) | |
Note: Clinical and clinicopathologic classification and staging were determined according to International Neuroblastoma Staging System (INSS) criteria.
Abbreviations: GNB, ganglioneuroblastoma; Sam68, Src-associated in mitosis with a molecular weight of 68 Kd.