Table 1. Clinical Characteristics of the Study Population for Circulating MiRNAs Profiling.
Control cases (n = 13) | UA patients (n = 13) | P value | |
Baseline data | |||
Sex, M/F | 5/8 | 7/6 | 0.431 |
Age (yrs) | 56±9 | 61±8 | 0.159 |
SBP (mm Hg) | 125±12 | 133±13 | 0.139 |
DBP (mm Hg) | 76±6 | 80±11 | 0.281 |
BMI (kg/m2) | 26±5 | 25±4 | 0.762 |
LVEF (%) | 69±6 | 68±6 | 0.624 |
HR (bpm) | 70±9 | 70±10 | 0.935 |
hs-CRP (mg/dl) | 1.18 | 1.25 | 0.951 |
PLT (×1012/L) | 225±72 | 209±43 | 0. 510 |
Glucose (mmol/l) | 5.02±0.83 | 4.95±0.51 | 0.806 |
Lipid profile | |||
LDL cholesterol (mmol/l) | 2.31±0.86 | 2.42±0.56 | 0.718 |
HDL cholesterol (mmol/l) | 1.02±0.23 | 0.97±0.30 | 0.630 |
TC (mmol/l) | 3.96±1.02 | 3.96±0.60 | 0.996 |
Risk factors | |||
Cigarette smoking, % | 7.7 | 23.1 | 0.593 |
Hypertension, % | 53.8 | 84.6 | 0.202 |
Diabetes mellitus, % | 15.4 | 30.8 | 0.645 |
Hyperlipemia, % | 53.8 | 61.5 | 0.691 |
Drug Administration | |||
Statin, % | 53.8 | 61.5 | 0.691 |
CCB, % | 30.8 | 38.5 | >0.99 |
Beta-blocker, % | 38.5 | 69.2 | 0.116 |
Aspirin, % | 38.5 | 61.5 | 0.239 |
Clopidogrel, % | 30.8 | 46.2 | 0.420 |
ACEI, % | 15.4 | 23.1 | >0.99 |
ARB, % | 15.4 | 15.4 | >0.99 |
BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; LVEF, left ventricular ejection fraction; HR, heart rate; PLT, platelet; CRP, C-reactive protein; LDL, low-density lipoprotein; HDL, high-density lipoprotein; TC, total cholesterol; CCB, calcium channel blocker; ACEI, angiotensin-converting enzyme inhibitor; and ARB, angiotensin receptor blocker. All P values represent comparisons between UA patients and controls. Comparisons between groups were performed with Student's t test or Mann–Whitney U test for continuous variables and with the Fischer exact test or χ2 test for categorical variables.