Table 4.
Effect of parental bipolar disorder on transmission of bipolar disorder to offspring, adjusted for sex of proband, history of sexual abuse of proband, sex of offspring, impulsive aggression of offspring, and sexual abuse of offspring
| Variable | Hazard ratio | 95% CI | Chi square | df | p-value | Model |
|---|---|---|---|---|---|---|
|
| ||||||
| Bipolar proband | 1.53 | 0.51–4.61 | 0.57 | 1 | 0.45 | R2 = 0.081 |
|
| ||||||
| Sex of proband | 0.58 | 0.17–2.03 | 0.72 | 1 | 0.40 | |
|
| ||||||
| Sexual abuse of proband | 1.04 | 0.32–3.33 | 0.00 | 1 | 0.95 | LRT = 36.3 |
|
| ||||||
| Sex of offspring | 2.86 | 0.89–9.16 | 3.12 | 1 | 0.08 | df = 11.5 |
|
| ||||||
| Impulsive aggression of offspring | 2.02 | 1.17–3.49 | 6.30 | 1 | 0.01 | p ≤ 0.001 |
|
| ||||||
| Sexual abuse of offspring | 6.03 | 2.08–17.45 | 10.97 | 1 | 0.001 | |
|
| ||||||
| Frailty | – | – | 6.23 | 5.88 | 0.38 | |
CI = confidence interval; df = degrees of freedom; LRT = likelihood ratio test.