Table 6.
Variable | Hazard ratio | 95% CI | Chi square | df | p-value | Model |
---|---|---|---|---|---|---|
| ||||||
Bipolar proband | 0.92 | 0.61–1.40 | 0.14 | 1 | 0.71 | R2 = 0.30 |
| ||||||
Sex of proband | 1.36 | 0.82–2.23 | 1.42 | 1 | 0.23 | |
| ||||||
Sexual abuse of proband | 1.48 | 1.01–2.17 | 3.96 | 1 | 0.05 | LRT = 152 |
| ||||||
Impulsive aggression of offspring | 1.60 | 1.36–1.89 | 31.08 | 1 | < 0.001 | df = 46.2 |
| ||||||
Sexual abuse of offspring | 1.61 | 1.05–2.48 | 4.76 | 1 | 0.03 | p ≤ 0.001 |
| ||||||
Frailty | – | – | 55.40 | 42.3 | 0.09 |
CI = confidence interval; df = degrees of freedom; LRT = likelihood ratio test.
The variable sex of offspring violated the proportional hazards assumption. Because bivariate analysis demonstrated offspring sex was not related to anxiety or substance use disorder risk [χ2(1) = 0.2, p = 0.635], this variable was dropped from the multivariate model. Results from the final, more parsimonious model are reported.