. Author manuscript; available in PMC: 2014 Dec 1.

Published in final edited form as: Free Radic Biol Med. 2013 Jun 15;65:10.1016/j.freeradbiomed.2013.06.017. doi: 10.1016/j.freeradbiomed.2013.06.017

Table 4.

Functionalities of Identified Proteins Differently Expressed

Functions	Proteins involved
Energy or mitochondrial dysfunction	Isocitrate dehydrogenase (NAD) subunit α (IDH3A) Isoform M1 Pyruvate kinase isozymes M1/M2 (KPYM) Pyruvate dehydrogenase E1 component subunit alpha (PDHA1) Aspartate aminotransferase (AATC) ATP synthase (ATPase) Pyruvate dehydrogenase component subunit beta, mitochondrial (PDH) Prohibitin (Fragment) (PHB) Triosephosphate isomerase (protect against neuronal apoptosis) (TPI) ES1 protein homolog, mitochondrial (ES1) Alpha-enolase (ENO)
Neuritic abnormalities	Actin-related protein 3 (Actr3) Dihydropyrimidinase-related protein 2 (CRMP-2)
Synaptic abnormalities and LTP	N-ethylmaleimide sensitive fusion protein attachment protein beta (SNAPs) Guanine nucleotide protein G (0) subunit alpha (GNAO)
Cell cycle; tau phosphorylation; and Abeta production	Pin-1
Lipid abnormalities	Isoform A of Cytosolic acyl coenzyme A thioester hydrolase (BACH)
Lysosomal dysfunction	V-type proton ATPase (V-ATPase)
Antioxidant defense	Protein DJ-1 (PARK7)