Case 1
|
Slightly pigmentednetwork |
Irregular and dishomogeneous dermalpapillae. Dendritic cells bulge from theepidermis toward the dermis forming“bridges” called mitochondria likestructures. |
An increased number of atypical melanocytes arranged around the dermal papillae. The atypical melanocytes protrude into thedermal papillae forming bridgesthus confirming the mitochondrialstructures in RCM. |
Disarrangement of the rete ridge and the increased number of atypical melanocytes. It is not possible to see the mitochondrial structure in this view. |
Case 2
|
Broadened pigmentednetwork |
Irregular and dishomogeneous dermalpapillae. Demarcated and non-demarcated rings were separated byloosely thick interpappilary spaces. |
Predominance of atypical melanocytes, isolated or in nests, enlarging the interpapillary spaces. |
Disarrangement of the rete ridge and the increased number of atypical melanocytes in the epidermis. |
Case 3
|
Typical network |
Rings of bright polygonal cellssurrounding roundish to oval darkareas corresponding to dermalpapillae at DEJ. The papillaelacked cytologic atypia. |
An increased number of isolated melanocytes are arranged aroundthe dermal papillae and thereare nevus cells nests within theepidermis. The interpapillaryspaces are preserved. |
Elongated rete ridges and presence of single and nests of nevus cells in the DEJ |
Case 4
|
Irregular globules |
Irregularly shaped clusters with cellsthat are nonhomogeneous inmorphologic features and reflectivity.Dense cell clusters consisted of largehomogeneous polygonal cells tightlyaggregated in a roundish regular structure. |
Large amount of atypicalmelanocytes predominantlyin nests with variablesize and shape within theepidermis and the dermis. |
Compact aggregates of atypical melanocytes with a slight intercellular discohesion, variable in size and shape, predominantly distributed at the DEJ and in the papillary dermis. |
Case 5
|
Regular globules |
Compact aggregates with sharpmargin of large polygonal cellssimilar in morphologic featuresand reflectivity, forming polyhedralstructures. |
Mostly singly nevocytes aroundthe papillae (at the DEJ) anddense nests composed of nevuscells within the dermis surroundedby a narrow band of epidermis. |
Singly nevus cells at the DEJ and well-circumscribed melanocytic nests composed of typical, large and monomorphous nevocytes, disposed in an organized manner within the dermis. |
Case 6
|
Pseudopods |
Compact aggregates of atypical cellsare distributed in a linear arrangementtoward the periphery with a densenest at the extremity, similar aglobulelike structure within theepidermis. |
Nests of atypical cells are arrangedin a linear manner throughoutthe periphery of the lesion. |
Nests of atypical melanocytes are distributed contiguously toward the periphery along the DEJ. |