Table 4. Features of studied subjects according to the tertiles of urinary sodium excretion and p22-phox C242T genotypes.
Characteristics | Low (<67 mEq/12 h) | Medium (67–111 mEq/12 h) | High (>111 mEq/12 h) | |||
p22-phox(C242T) Genotype | CC | CT+TT | CC | CT+TT | CC | CT+TT |
N (%) | 184 (43) | 247 (57) | 178 (42) | 248 (58) | 194 (44) | 247 (56) |
Clinical | ||||||
Age, years | 41.7±0.7 | 43.1±0.7 | 43.9±0.8 | 42.7±0.6 | 44.8±0.8 | 43.9±0.7 |
Gender (Male/Female) | 75/109 | 93/152 | 97/81 | 97/153 | 113/81 | 154/93 |
Systolic blood pressure, mmHg | 121.9±1.5 | 121.5±1.3 | 124.7±1.4 | 121.2±1.0 | 125.5±1.2 | 129.1±1.3* |
Diastolic blood pressure, mmHg | 80.4±1.0 | 79.1±0.8 | 82.0±0.9 | 80.6±0.7 | 83.9±0.9 | 86.9±0.9* |
Body mass index, kg/m2 | 25.1±0.4 | 25.2±0.3 | 25.7±0.3 | 24.9±0.3 | 26.2±0.3 | 27.1±0.3 |
Smoking, n (%) | 48 (26) | 51 (21) | 43 (24) | 51 (20) | 44 (23) | 69 (28) |
Hypertension, n (%) | 53 (29) | 65 (26) | 61 (34) | 73 (29) | 80 (41) | 124 (50) |
Diabetes mellitus, n (%) | 33 (18) | 34 (14) | 23 (13) | 41 (16) | 28 (14) | 54 (22) |
Race (Caucasian-descent), n (%) | 84 (46) | 105 (43) | 67 (38) | 108 (43) | 85 (44) | 89 (36) |
Serum analysis | ||||||
Glycemia, mg/dL | 100.6±2.2 | 99.5±1.2 | 100.9±1.8 | 101.9±1.7 | 102.4±2.1 | 104.8±2.0 |
Uric acid, mg/dL | 4.5±0.1 | 4.7±0.1 | 4.7±0.1 | 4.4±0.1 | 5.2±0.4 | 5.0±0.1 |
Creatinine, mg/dL | 0.97±0.16 | 0.93±0.01 | 0.96±0.01 | 0.94±0.01 | 0.98±0.01 | 1.00±0.01 |
Triglycerides, mg/dL | 123.6±7.1 | 113.8±5.0 | 123.1±6.7 | 120.6±5.7 | 139.6±7.1 | 148.0±7.1 |
HDL-cholesterol, mg/dL | 54.7±2.8 | 50.1±1.8 | 49.6±2.1 | 49.4±1.7 | 52.6±3.1 | 50.7±2.2 |
LDL-cholesterol, mg/dL | 138.2±2.9 | 141.5±2.5 | 138.5±3.2 | 140.1±2.5 | 140.2±2.9 | 137.4±2.3 |
12 h urinary analysis | ||||||
Sodium, mEq | 43.4±1.1 | 44.6±0.9 | 85.7±0.9 | 87.7±0.8 | 156.7±3.2 | 161.5±3.3 |
Potassium, mEq | 16.2±0.7 | 16.6±0.7 | 20.5±0.8 | 22.0±0.8 | 32.3±1.5 | 29.6±0.9 |
Legend. HDL – high-density-lipoprotein; LDL – low-density-lipoprotein;
p<0.05 in comparison with CC genotype.