Table 2. Amino acid variation in Gag p17 and p24 specific for HLA-B*57/58:01.
| AA | Comparison | AA variation*** | ||||
| Position | SH | HLA-B*57/58:01 | Non-B*57/58:01 | |||
| SH value* | Z score** | Dominant | Minor | Dominant | Minor | |
| I147 | 0.44 | −120 | L | MI | I | L |
| V159 | 0.80 | −54 | IV | V | I | |
| S173 | 0.68 | −65 | ST | S | AT | |
| T242 | 0.05 | −400 | N | TS | T | |
| G248 | 0.78 | −47 | GA | T | G | A |
| T280 | 0.88 | −19 | TV | SIA | T | VSA |
*The Sequence Harmony (SH) score represents overlap in amino acid composition between the two groups analyzed (HLA-B*57/58:01 versus non-HLA-B*57/58:01). An SH value of 0 indicates no overlap (largest possible differences) while a value of 1 indicates complete overlap (no differences).
**All Z scores represent P values <0.0001 with correction for multiple testing (450 alignment positions).
***The most frequent amino acids found at a certain position are depicted as “Dominant”, whereas the “Minor” amino acids are present at least 2 times less frequent than the most frequently occurring amino acid at this position. Amino acids are ordered from highest to lowest frequency.