. 2013 Dec 5;8(12):e81235. doi: 10.1371/journal.pone.0081235

Table 3. Amino acid variation in Gag p17 and p24 associated with HLA-B^*57/58:01 disease progression.

AA	Comparison		AA variation^***
Position	SH		Progressors		LTNPs
	SH value^*	Z score^**	Dominant	Minor	Dominant	Minor
S126	0.83	−10.7	SK	N	S	N
L215	0.61	−27.8	LT	I	L	M

*The Sequence Harmony (SH) score represents overlap in amino acid composition between the two groups analyzed (HLA-B*57/58:01 progressors versus HLA-B*57/58:01 LTNPs). An SH value of 0 indicates no overlap (largest possible differences) while a value of 1 indicates complete overlap (no differences).

**All Z scores represent P values <0.0001 with correction for multiple testing (450 alignment positions).

***The most frequent amino acids found at a certain position are depicted as “Dominant”, whereas the “Minor” amino acids are present at least 2 times less frequent than the most frequently occurring amino acid at this position. Amino acids are ordered from highest to lowest frequency.

Table 3. Amino acid variation in Gag p17 and p24 associated with HLA-B*57/58:01 disease progression.

Table 3. Amino acid variation in Gag p17 and p24 associated with HLA-B^*57/58:01 disease progression.