Table 1. Univariate and multivariate analysis of overall survival and progression free survival results of 556 patients from TCGA dataset (a) and 91 OC patients from MDACC (b, c) - Data Portal (https://tcga-data.nci.nih.gov/tcga).
| a. OS (n = 556) | |||||
|---|---|---|---|---|---|
| Variable | Univariate analysis | Multivariate analysis | |||
| HR (95%CI) | P value | HR (95%CI) | P value | ||
| EphA2 | Low vs. High | 0.62 (0.48-0.8) | 0.0002 | 0.78 (0.7-1.01) | 0.0575 |
| EphB2 | Low vs. High | 0.69 (0.53-0.9) | 0.0051 | 0.93 (0.73-1.2) | 0.5972 |
| miR-520d-3p | Low vs. High | 1.29 (1.02-1.63) | 0.03 | 1.32 (1.03-1.69) | 0.0297 |
| DICER1 | Low vs. High | 1.43 (1.11-1.82) | 0.0032 | 0.94 (0.73-1.21) | 0.6271 |
|
Cytoreduction
operation |
(Residual disease vs. no residual disease) |
0.94 (0.62-1.43) | 0.77 | 0.92 (0.6-1.41) | 0.6935 |
| b. OS (n = 91) | |||||
| MiR-520d-3p | Low vs. High | 1.873 (1.026-3.420) | 0.041 | 3.168 (1.654- 6.066) |
0.0005 |
| Recurrence | Positive vs. Negative |
29.967(1.587-565.723) | 0.023 | ||
| Dicer_di | Low vs. High | 2.518(1.396-4.542) | 0.002 | 2.551(1.306-4.984) | 0.0061 |
| Drosha_di | Low vs. High | 2.594(1.431-4.705) | 0.002 | 2.471(1.220-5.003) | 0.0119 |
| c. PFS (n = 91) | |||||
| MiR-520d-3p | Low vs. High | 2.183 (1.208-3.944) | 0.01 | 2.871 (1.563- 5.275) |
0.0006 |
|
Cytoreduction
operation |
Suboptimal vs. optimal |
1.638 (0.864-3.102) | 0.007 | ||
| Node metastasis | Positive vs. Negative |
2.458 (1.091-50658) | 0.03 | ||
| Dicer_di | Low vs. High | 2.396 (1.319-4.355) | 0.004 | 3.224 (1.7444- 5.959) |
0.00018 |
| Drosha_di | Low vs. High | 2.244 (1.241-4.060) | 0.008 | ||